A heartbreaking work of staggering genius

From Wikipedia: A Heartbreaking Work of Staggering Genius (ISBN 0-330-48455-9) is a memoir by Dave Eggers released in 2000. It chronicles his stewardship of younger brother Christopher "Toph" Eggers following the cancer-related deaths of his parents.

The book was an enormous commercial and critical success, reaching number one on The New York Times bestseller list and being nominated as a finalist for the Pulitzer Prize for General Non-Fiction. Time magazine and several newspapers dubbed it "The Best Book of the Year". Critics praised the book for its wild, vibrant prose, and it was described as "big, daring [and] manic-depressive" by The New York Times. The book was chosen as the 12th best book of the decade by The Times